Mycobacterium tuberculosis is an intracellular organism, the ability of Mycobacterium tuberculosis to cause devastating lung disease in immune hosts allows it to spread effectively through the respiratory pathway in the population. The main hypothesis is that Mycobacterium tuberculosis causes chronic inflammation and thus promotes lung cancer. There are many hypotheses that M.tb infection causes lung cancer, such as immune system suppression, DNA damage, and the production of inflammatory factors. A weakened immune system is more likely to lead to disease, but whether it will elevate the risk of lung cancer is debatable. Mycobacterium tuberculosis infections can also trick the body's innate immune, which can be partially suppressed by Mycobacterium tuberculosis. About a third of people are infected with Mycobacterium tuberculosis, and about 1.4 million people died from TB in 2019 ( ). Tuberculosis (TB) is another major public health problem worldwide, which is caused by Mycobacterium tuberculosis. It's the largest cause of death among men, and the third leading cause of cancer in women, after breast and colorectum cancer. ![]() The World Health Organization reported that about 1.76 million people worldwide die of lung cancer each year ( ). It is well known that lung cancer is now a public health issue as the leading cause of cancer-associated deaths in the world.
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